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Original Article
Changes in Mean Platelet Volume and Platelet Distribution Width after Therapy in Childhood Idiopathic Thrombocytopenic Purpura
Jong Tai Kim, Kyung Won Lee, Soon Nam Kim, Moon Kyu Kim
Clin Exp Pediatr. 2002;45(4):505-511.   Published online April 15, 2002
Purpose : Mean platelet volume(MPV) and platelet distribution width(PDW) are useful parameters in evaluating disorders of platelets. In cases with idiopathic thrombocytopenic purpura(ITP), they change as platelet count increases. In this study, we compared the values of MPV and PDW in ITP patients at diagnosis with those of normal children. We also studied whether the early changes in MPV may...
Case Report
A Case of Intestinal Perforation in Henoch-Sch nlein Purpura
Won Sik Kang, Chang Hwan Oh, Jae Young Kim, Young Taek Lee, Hye Jin Lee, Hee Jin Kim, Sung Won Kim
Clin Exp Pediatr. 2002;45(3):406-412.   Published online March 15, 2002
Henoch-Sch nlein purpura(HSP) is one of the most common vasculitic diseases of childhood, referred to as a leukocytoclastic vasculitis affecting small vessels. Although HSP related gastrointestinal symptoms are seen in up to 80% of patients during acute illness, these symptoms are usually transient. However, some patients with HSP have gastrointestinal major surgical complications such as intussusception, bowel infarction, necrosis, stricture,...
Small Intestinal Infarction Associated with Henoch-Schöenlein Purpura
Myung Ki Han, Yu In Park, Jeong Ho Kim, Jung Joo Lee, Hye Young Kang
Clin Exp Pediatr. 2002;45(1):125-130.   Published online January 15, 2002
Henoch-Schöenlein purpura, also known as anaphylactoid purpura, is characterized by palpable purpura, colicky abdominal pain, gastrointestinal hemorrhage, arthralgias, and renal involvement. Histopathologically, the condition represents a vasculitis, and in fact, it may be the most common vasculitis syndrome affecting children. The pathogenesis of Henoch-Schöenlein purpura remains poorly understood, but it is postulated that an unknown antigenic stimulus causes elevation of circulating IgA and that complement...
Original Article
Study of Autoantibodies Against Platelet GP IIb/IIIa and GP Ib/IX in Childhood Chronic Idiopathic Thrombocytopenic Purpura
Chanwook Woo, Junghwa Lee, Kwangchul Lee, Soonkyum Kim
Clin Exp Pediatr. 2000;43(3):395-401.   Published online March 15, 2000
Purpose : Chronic idiopathic thrombocytopenic purpura(CITP) is an autoimmune disease caused by autoantibodies reacting to certain antigens, and platelet glycoprotein(GP) IIb/IIIa and GP Ib/IX complexes are thought to be some of those antigens. However, the clinical significance of anti-GP autoantibodies in CITP patients is unknown. In this study, we investigated the clinical correlation between the presence of circulating autoantibodies against...
Relation between Renal and Scrotal Involvement in Henoch-Schönlein Purpura
Eui Seong Lee, Pyung Kil Kim, Young Kwan Park, Hae Won Cheon, Kee Hwan Yoo
Clin Exp Pediatr. 2000;43(2):260-266.   Published online February 15, 2000
Purpose : Although Henoch-Schönlein purpura(HSP) has been described in detail, there is a paucity of information describing scrotal involvement and risk factors for renal involvement. This study was performed to evaluate the incidence of scrotal involvement and the relationship between renal and nonrenal involvement, including scrotal involvement. Methods : We retrospectively reviewed medical records of 164 male children who were diagnosed...
Case Report
Dapsone in a Case with Chronic Recurrent Henoch-Schönlein Purpura
Jin Choi, Soo Jung Lee, Dae Kyun Koh
Clin Exp Pediatr. 1999;42(11):1574-1578.   Published online November 15, 1999
The most clearly delineated condition with prominent cutaneous leukocytoclastic vasculitis which presents to a pediatrician is Henoch-Schönlein purpura. There is general agreement that in Henoch-Schönlein syndrome the skin manifestations have a very benign long-term course and that corticosteroids are of little value. Dapsone appears to be of special value in diseases characterized by an accumulation of polymorphonuclear neutrophils notably leukocytoclastic...
Original Article
Study on Anti-neutrophil Cytoplasmic Antibodies in Children with Henoch-Schölein Purpura
Shin Jong Lee, Woo Yeong Chung, Chul Ho Kim, Jeong Nyeo Lee
Clin Exp Pediatr. 1995;38(7):970-975.   Published online July 15, 1995
The presence of IgG, IgA and IgM antineutrophil cytoplasmic antibodies(ANCA) were inves-tigated in 32 children with Henoch-Schölein Purpura(HS purpura), in 14 children with HS pur-pura nephritis who were confirrned by renal biopsy and in 12 control children using flow cytom-etry(FASCan, Beckton-Dickinson, Co, USA) and indirect immunofluorescence technique(Sigma Diagnostics, USA). There were no evidence of IgG, IgA or IgM cytoplasmic ANCA(p-ANCA),...
A Comparative Study o fIntavenous Methylprednisolone Dosage for Treatment of Children with Acute Idiopathic Thrombocytopenic Purpura
Eun Ju Shin, Yeong Jae Song, Woo Yeong Chung, Tae Gyu Hwang, Soon Yong Lee
Clin Exp Pediatr. 1995;38(4):513-519.   Published online April 15, 1995
Purpose : It is well known that use of intranenous methylprednisolone(IVMP)for the patients with idiopathic thrombocytopenic purpura(ITP) is not only as effective as use of intravenous gammaglobulin to mincrease platelets quickly, but also the former is less expensive than the latter. As the adequate dosage of IVMP has not been fully elucidated, we have tried to determine it. Methods : The...
EEG Abnormalities in Henoch-Schölein Purpura
Hae Wom Cheon, Dong Gun Park, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(11):1600-1606.   Published online November 15, 1994
Schölein-Henoch purpura is a generalized small vessel vasculitis characterized by non-thrombocytopenic purpura, arthritis, abdominal pain and nephritis. In 1913 Osler described an allergic purpura associated with hemiplegia. After then Lewis et al. Reported the cases of Schölein-Henoch purpura associated with convulsion, coma, confusion, intracranial hemorrhage, and chorea, CNS complication has been reported in 1-8% of children and subsided spontaneously in...
Clinical Studies of Henoch-Schölein Purpura Which was Considered as Acute Abdomen
Seong Young Jeong, Seong Yun Cho, Chio Heong Park, Seong Ho Cha, Byoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1993;36(8):1124-1132.   Published online August 15, 1993
Henoch-Schölein purpura is a common pediatric disease presenting most frequently with skin, gastrointestinal, joint and renal manifestations. But in cases are infrequently only severe gastointestinal manifestations. It is hard to diagnose promptly and exactly. Clinical manifestations and laboratory findings were observed and analyzed in 20 cases with Henoch-Schölein purpura which were considered as acute abdomen, hospitalized at Kyung Hee university Hospital...
Case Report
Three Cases of Purpura Fulminans
Sun Hee Suh, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim
Clin Exp Pediatr. 1993;36(5):725-732.   Published online May 15, 1993
Purpura fulminans is one of rare consumptive coagulopathy in children. The most common prediasposing conditions of purpura fulminans are infectious disease like streptococcal infection and chickenpox. This disease is characterized by ecchymotic lesions that are usually distributed symmetrically on the lower extremities and buttocks. These ecchymotic lesions undergo necrosis, unless there is effective treatment. We experienced 3 cases of purpura fulminans...
A Case of Intestinal Necrosis Associated with Henoch-Schönlein Purpura
Soo Jung Lee, Young Yoo Kim, Sung Soo Whang, Kyung Yil Lee, Won Ik Lee, Jeong Soo Kim, Chang Joon Ahn, Mi Kyung Jee
Clin Exp Pediatr. 1992;35(9):1291-1297.   Published online September 15, 1992
Gastrointestinal symptoms of Henoch-Schönlein commonly present abdominal pain, nausea, nomitting, melena and hematemesis and resolve mostly without any complications. Some times life threatening gastrointestinal manifestations such as massive hemorrhage, intussusception, intestinal necrosis and perforation may develop We report a case of the Henoch-Schönlein purpura with intestinal lesion in 11 year female patient who presented with colicky abdominal pain and bloody stool...
Neonatal Purpura Fulminans due to Homozygous Protein C Deficiency
Jae-Hong Park, Sung-Sub Sim, Soo-Young Kim, Hee-Joo Jeon, Chan-Yung Kim, Hong Keun Oh, Jin-Yeong Jeong
Clin Exp Pediatr. 1992;35(5):696-703.   Published online May 15, 1992
Homozygous protein C deficiency is a rare herediatary disorder of blood coagulation resulting in microvascular and venous thromboses, usually purpura fulminans, starting shortly after birth. Protein C serves to inactivate the active forms of factor V and VIII, and increase the rate of fibrin degradation. For confirmation of homozygous protein C deficiency, the infant should have undetectable protein...
Original Article
Clinical analysis and prognostic factors in Henoch-Schonlein purpura .
Ha Young Lee, Chong Sung Chung, Kyu Chul Choeh, Byoung Soo Cho, Young Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1991;34(5):682-690.   Published online May 31, 1991
This study was undertaken to evaluate the prognostic factors of recurrence and renal involvement in Henoch-Sch公nlein purpura. Total 110 cases of anaphylactoid purpura below 15 years of age who admitted to Pediatric Departmen of Kyung Hee University for 8 years from January 1st 1979 to December 31st 1986 were analyzed clinically and statistically. The results were obtained as follows. 1) The peak incidence of age was 4...
Changes of immune indices in children with recurrent gross hematuria (IgA nephropathy and non-IgA nephropathy) and Henoch-Schonlein purpura nephritis.
Seong Mi Kim, Myung Chul Hyun, Cheol Woo Ko, Ja Hoon Koo, Doo Hong Ahn, Jung Sik Kwack
Clin Exp Pediatr. 1991;34(3):317-322.   Published online March 31, 1991
A Prospective study was conducted to see the changes of immune system in recurrent gross hematuria (IgA nephropathy and non-IgA nephropathy) and HSP nephritis in children. Study patients consisted of 60 children with recurrent gross hematuria and Henoch-schdnlein purpura nephritis (8 IgA nephropathy, 24 non-IgA nephropathy and 28 HSP nephritis). The cellular immune indices (total T, T4, T8 cells and T4/T8 ratio) and humoral...
Relationship between anaphylactoid purpura and Beta-Hemolytic Streptococcal Infection.
Ji Eun Lee, Young Sook Kang, Joon Sik Kim, Sung Ho Kim, Chin Moo Kang
Clin Exp Pediatr. 1990;33(9):1231-1236.   Published online September 30, 1990
Relationship between anaphylactoid purpura and beta-hemolytic streptococcal infection was obser- ved and analyzed through clinical manifestation and labortory findings in 146 cases of allergic purpura, hospitalized at Dongsan hospital, Keimyung University during the period from January, 1981 to May, 1987. The following results were obtained. 1) The age distribution of anaphylactoid purpura showed a peak incidence between 2 to 7 years of age and male preponderance was...
A case of Henoch -Schönlein purpura associated with scarlet fever.
Hee Shang Yoon, Byung Kiu Park, Myung Kul Yum
Clin Exp Pediatr. 1989;32(11):1581-1585.   Published online November 30, 1989
We experienced an interesting case of Henoch-Schönlein purpura associated with scarlet fever in a 10-year-old girl. Typical two rashes representing Henoch-Schönlein purpura and scarlet fever appeared simultaneously. Fine erythematous maculopapular eruptions (goose-skin appearance) and straw-berry tongue, characteristic of scarlet fever, were present above the pelvis with varing sized purpuras, characteristic of Henoch-Schönlein purpura, below the pelvis.
A Clinical Study of Henoch-Schönleln Purpura in Childhood.
Y S Choi, H J Kwon, H Seong, C H Choi
Clin Exp Pediatr. 1989;32(1):67-74.   Published online January 31, 1989
The authors experinced 94 cases of Henoch-Schönlein purpura in chilhood during the period form January, 1981 to Junly, 1987. The summary of the clinical and laboratory observations are as follows. 1) Male to female ratio was 1.4 : 1 and the age distribution of Henonoch-Schönlein purpura in showed a peak incidence between 3 to 10 years of age (79%). 2) In seasonal incidence, the...
A Case of Thrombotic Thrombocytopenic Purpura in Childhood.
Dong Kun Hyun, Jung Bae Lee, Chang Hyun Yang, Kir Young Kim
Clin Exp Pediatr. 1988;31(4):511-518.   Published online April 30, 1988
Thrombotic thrombocytopenic purpura is clinically characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, renal disorder and transient bizarre neurological symptoms. Its essential histological lesion consists of numerous complete or, more often, incomplete occlusions of the arterioles and capillaries by hyaline material. We have experienced a case of thrombotic thrombocytopenic purpura in infancy. The patient was a one year and 4 month-old who complains petechiae on the...
The Role of Anitiplatelet Antibody and the Therapeutic Effect of High-Dose I.V. gamma-globulin in Childhood Idiopathic Thrombocytopenic Purpura.
Kyu Chul Choi, Sang Ho Park, Yong Mook Choi
Clin Exp Pediatr. 1988;31(2):212-219.   Published online February 28, 1988
Among 48 children with I.T.P (26 acute, 10 chronic and 12 undetermined), the antiplatelet antibody test (APA) was qualitatively studied by indirect immunofluorescent method in 34 patients of which only 25 patients (18 acute and 7 chronic) were able to follow-up. The overall positivity of APA was 36% and there was no relationship with disease chronicity. Intravenous r-globulin was given at a dose of...
A Case Report of Isoimmune Neonatal Thrombocytopenie Purpura.
Hye Ran Byun, Kyung Ha Ryu, Soon Hee Kim, Moon Ja Kim, Keun Lee
Clin Exp Pediatr. 1987;30(12):1452-1455.   Published online December 31, 1987
Isoimmune thrombocytopenic purpura is an uncommon cause of purpura in the newborn infant, caused by fetal-maternal platelet incompatibility. The maternal isoantibodies against fetal platelet antigens, which are lacked in mother’s platelets, cross placenta and cause destructions of baby’s platelet. A bady bom with IITP was diagnosed in the first day of life and treated successfully with platelet concentrate of mother’s blood.
Idiopathic Thrombocytopenic Purpura in Children.
Kyu Chul Choi, Sang Ho Park, Yong Mook Choi
Clin Exp Pediatr. 1987;30(6):664-670.   Published online June 30, 1987
Forty four children with idiopathic thrombocytopenic purpura (ITP) were analyzed retrospectively and the following prognostic factors were obtained in response to treatments and clinical courses. And 73.5% of all cases were recovered within 6 months after onset (acute ITP). The patients who were admitted within 1st or 2nd week after onset showed more favorable prognosis with significance (p<0.05 and p< 0.005, respectively). The patients...
Clinical Studies of Anaphylactoid Purpura in Childhood.
Kwang Hyun Kim, Kwang Nam Kim, Ha Baik Lee, Hang Lee
Clin Exp Pediatr. 1985;28(6):545-554.   Published online June 30, 1985
Anaphylactoid purpura or Henoch-Schonlein purpura is a common pediatric disease presenting most frequently with purpura, and occasionally with gastrointestinal and joint manifestations, and has been known to present pathologically with diffuse vasculitis involving small blood vessles in many organs. Clinical manifestations and laboratory findings were observed and analyzed in 110 cases with anaphylactoid purpura hospitalized at Hanyang University Hospital during...
The Effect of Intravenous Gammaglobulin for Acute Idiopathic Thrombocytopenic Purpura in Children.
Seung In Baek, Geum Joo Kim, Kuhn Soo Lee, Sang Bum Lee, Doo Hong Ahn
Clin Exp Pediatr. 1985;28(5):483-491.   Published online May 31, 1985
A clinical study was conducted to determined the effectiveness of intravenous gammaglobulin on childhood acute ITP. Study group consisted of 8 children who were treated with IV Globulin(0.4 gm/kg/d, 5 days) only or combined with steroid, and control group of 19 children who were treated with steroid only. Study period was from January 1980 to June 1984, and following results...
Clinical Study of Idiopathic Thrombocytopenic Purpura in Children.
Kwang Nam Kim, Sang Hee Cho, Je Hoon Shin, Woo Gill Lee
Clin Exp Pediatr. 1985;28(3):251-257.   Published online March 31, 1985
The authors studied 26 cases with idiopathic thrombocytopenic purpura who were admitted to Department of Pediatrics Hanyang University Hospital. The results were as follows: 1)The peak incidence of age was 5 to 7 years old. Male to female ratio was 2.7 : 1 which showed: slight male preponderance. 2)lThe most prevalent seasons were spring and summer. In both seasons, the...
A Study on Purpura in Children.
Jong Sub Lee, Kyung Ho Kim, Ki bok Kim
Clin Exp Pediatr. 1983;26(2):151-157.   Published online February 28, 1983
We have seen 96patients who were admitted with purpura to the Pediatric Department of Kwangju Christian Hospital during the period of 10 years from Jan., 1971 to Dec., 1980. The following observations were made; 1) Leukemia(26 cases, 27.0%) was the most common underlying disease, followed by allergic purpura (25 cases, 26.0%), idiopathic thrombocytopenic purpura (22 cases, 22.9%), Aplastic Anemia (13 cases, 13.5%), sepsis (5 cases,...
Clinical Studies in purpuras in Children.
Man Ki Hong, Kyung Sik Nho, Kyung Tai Whang, Kyung Soo Lee
Clin Exp Pediatr. 1983;26(1):41-47.   Published online January 31, 1983
Clinical observations was made on 191 cases of children with purpura who admitted to the pediatric department of St. Mary’s Hospital College from Jan, 1971 to Dec, 1980. Boys were： 116 cases and girls were 75 cases . The results were as follows. 1. Allergic purpura was the most common cause of purpura, followed by leukemia, idiopa-thic thrombocytopanic purpura, aplastic anemia in order...
A Clinical Study on Anaphylactoid Purpura.
T K Yoon, T H Lee, S M Shin, S J Lee
Clin Exp Pediatr. 1981;24(12):1185-1192.   Published online December 15, 1981
Anaphylactoid purpura is a common disease in childhood and manifests variable clinical features including hepatomegaly. We analyzed 35 children who were admitted and diagnosed as anaphylactoid purpura at Soon Chun Hyang hospital during the periods of 5 years from September, 1975 to August 1980. The results were as follows: 1)It more frequently affected male than female, in the ratio...
Clinical Study on Henoch-Schonlein Purpura.
Eun Hee Kang, Won Young Kang, Taek Sae Lee, Ki Chang Han
Clin Exp Pediatr. 1981;24(11):1083-1091.   Published online November 15, 1981
Diagnostic Value of Serum Immunoglobulins in Glomerulonephritis.
Pyung Kil Kim, Kyo Sun Kim, Chul Lee, Nan Ae Kim, Jae Seung Lee
Clin Exp Pediatr. 1981;24(7):652-658.   Published online July 15, 1981
Serum immunoglobulin concenatrations were measured in 156 patients with various types of glomerulonephritis such as acute poststreptococcal glomerulonephritis, minimal lesion nephrotic syndrome and Henoch-Sch?lein purpura nephritis. 1) Serum IgG level was above normal mean in acute poststreptococcal glomerulonephritis, and normal range in Henoch-Scholein purpura nephritis. Serum IgG concentrations were significantly reduced in minimal lesion nephrotic syndrome. 2) Serum IgA concentrations...
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